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Aim: The aim of this research was to evaluate the impact of a telerehabilitation program on physical fitness, muscle strength, and levels of depression and anxiety in post-COVID-19 patients. Methods: Thirty-two individuals recovered from COVID-19 (48.20±12.82 years) were allocated into either a telerehabilitation (TG n=16) or control (CG n=16) group. Physical fitness, handgrip strength, depression and anxiety levels were assessed before and after an 8-week intervention. Results: There was a significant improvement in muscle strength in both groups. Physical fitness significantly increased compared to the CG at the end of the intervention. Levels of anxiety and depression significantly decreased after the intervention when compared to the CG. Conclusion: Eight weeks of functional telerehabilitation training is a viable and efficient way to rehabilitate patients affected by COVID-19, as it improved physical conditioning and mental health. © 2023, University Library System, University of Pittsburgh. All rights reserved.
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Objectives: Mucormycosis is a rare invasive fungal infection with high lethality, affecting mainly patients with hematological neoplasia, decompensated diabetes, and covid-19 infection. The aim was to perform a cost-effectiveness analysis of liposomal Amphotericin B (standard treatment) versus isavuconazole for treating mucormycosis in the consolidation phase from the perspective of the Brazilian Unified Health System. Method(s): A decision tree model was built. The analysis considered the costs of the treatment over a six-month time horizon. This included hospitalization during the entire course of treatment and the expenditures related to dialysis, complication occurring in 5% (3%-6%) of cases treated with the Amphotericin B. Appointments with specialists were included in the isavuconazole arm, and amphotericin B was used if the patient failed to respond to isavuconazole. The utility of the patient with mucormycosis, cured and with renal failure was estimated. Uncertainties were assessed through probabilistic and deterministic sensitivity analyses. Result(s): The average cost of amphotericin B and isavuconazole arm was R$1.054.874,39 and R$522.344,05, respectively. The utility was 0.479 with amphotericin B and 0.480 with isavuconazole. The ICER was R$ -684,494,237 (dominant). In deterministic sensitivity analysis, the probability of dialysis was the variable with the greatest impact. In probabilistic analysis, the ICER is distributed in the right and left lower quadrant, the acceptability curve for all the scenarios analyzed is favorable for isavuconazole. The budget impact suggests a potential savings of between R$ 350 million and R$ 415 million over five years. Conclusion(s): The treatment of mucormycosis during the consolidation phase with isavuconazole represents a lower cost, besides the convenience of oral treatment and reduced incidence of severe adverse events, with mortality similar to the Amphotericin B arm. In Brazil, the formulation of posaconazole approved is inadequate for treating mucormycosis during the consolidation phase, therefore isavuconazole is the single oral drug available.Copyright © 2023
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The world is facing a serious viral infection caused by the new Severe Acute Respiratory Syndrome Coronavirus 2. We aimed to evaluate and map the high-risk clusters of COVID-19 in the State of Alagoas, a touristic area in northeastern Brazil, after two years of pandemic by a population-based ecological study, using COVID-19 cases reported in the State of Alagoas, between March, 2020 and April, 2022. We performed a descriptive and statistical analysis of epidemiological data. We then map high-risk areas for COVID-19, using spatial analysis, considering the incidence rate by municipality. 297,972 positive cases were registered;56.9% were female and 42.7% aged between 20 and 39 years old. Men (OR = 1.59) and older than 60 years old (OR = 29.64) had a higher risk of death, while the highest incidence rates of the disease occurred in the metropolitan region. Our data demonstrate the impact of COVID-19 in the State of Alagoas, through the two years of pandemic. Although the number of cases were greater among women and young adults, the chance of death was greater among men and older adults. High-risk clusters of the disease initially occur in metropolitan cities and tourist areas.
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Objective: to verify associations between sociodemographic variables and factors that facilitate and hinder the transition from face-to-face psychological care to remote mode in the first year of the COVID-19 pandemic. Method: this is an analytical, quantitative, cross-sectional study. After approval by the Research Ethics Committee, data collection was performed by applying an online form consisting of 55 questions. Data were analyzed using descriptive and inferential statistics techniques. Results: the intentional sampling consisted of a total of 385 Brazilian psychologists, mostly women (67.01%), young professionals with up to five years of graduation (44.16%) most of activities in the private clinic. It was found that training time between five and 10 years was associated with a greater perception of difficulties and that previous experience with remote care facilitated adaptation in the transition from one modality to another. Conclusion: considering that call center can be a powerful tool in the health scenario, it is suggested the inclusion of remote care issues in the research agenda and syllabus in the curricula of health training courses.
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Objectives: Patients with Systemic Lupus Erythematosus (SLE) are predisposed to serious infections due to immunocompromise, comorbidities, immunomodulatory and/or immunosuppressive therapy, as well as the lack of these medications faced by patients dependent on the Sistema Unico de Saude (SUS) during the COVID-19 pandemic. Studies revealed a low risk of worsening disease activity after vaccination against SARS-CoV-2 and safety in the continuity of immunomodulatory therapy during the vaccination stages. Thus, immunization against COVID-19 is an important pillar in reducingmorbidity and mortality related to infectious conditions and SLE. This study had the objective to understand the disease activity in SLE patients after vaccination against COVID-19. Method(s): This is an observational, longitudinal, ambidirectional study with follow-up of subgroups of patients with immune-mediated rheumatic diseases immunized with vaccines made available by the Programa Nacional de Imunizacao (Butantan Institute, Pfizer/BioNTech, BioManguinhos/Fiocruz and Janssen). Data from the SLE disease activity index 2000 (SLEDAI-2 K) and sociodemographic data were collected and stored via an online platform, with a comparison of the index before and after each dose. This study was approved by the local Research Ethics Committee, and it is associated to the SAFER Project from Brazilian Society of Rheumatology. Result(s): A total of 223 patients were included, of which 83% were female and 39% had SLE, 36.7 +/- 11.76 years old. Regarding the disease activity, at inclusion the mean PGA score(SD) was 2,61 +/- 2,77. After the 1st dose it was 1.38 +/- 2.17, after the 2nd dose it was 2,35 +/- 2,99, after the 3rd dose it was 2,19 +/- 2,58 and after the 4th dose 1.18 +/- 1.88. The mean SLEDAI-2 K score at inclusion was 7,27 +/- 9,70, after the 1st dose it was 2,75 +/- 5,29, after the 2nd dose it was 4,73 +/- 6,40, after the 3rd dose 3,33 +/- 5,51 and after the 4th dose 2.12 +/- 4.27. 6% of the patients referred worsening disease activity after the 1st dose, 14,3%after the 2nd dose, and no patient reportedworsening of disease activity after the 3rd and 4th doses. Conclusion(s): Vaccination did not contribute toworsening disease activity of the SLE patientss studied, according to the indices used to assess disease activity.
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Objectives: Immunization against SARS-CoV-2 is an effective strategy to reduce morbidity and mortality in the face of the COVID-19 pandemic. People with Immune-mediated Rheumatic Diseases (IMRD) also benefited from this campaign. However, there is a limited amount of data on the outcome of vaccination in these patients, in terms of those who were infected by the virus. This study had the objective to evaluate the rate of COVID-19 cases in patients with IMRD after vaccination against SARS-CoV-2. Method(s): Observational, longitudinal and ambidirectional study with follow-up of subgroups of patients with IMRD immunized with vaccines made available by the National Immunization Plan (inactivated adsorbed vaccine registered by the Instituto Butantan (IB), recombinant vaccines registered by Bio Manguinhos/ Fiocruz and by Janssen, and Pfizer/BioNTech). Sociodemographic data and questionnaires on flu syndrome, laboratory confirmation of infection and need for hospitalization and outcomes were collected and stored via an online platform. This study is associated to the SAFER Project from the Brazilian Society of Rheumatology and it was approved by the local Research Ethics Committee. Result(s): A total of 223 patients aged over 18 years, mean age 42.79 +/- 15.18 years, were included. All were within the inclusion/exclusion criteria, with 83% being female. The main IMRD included were systemic lupus erythematosus (39%) and rheumatoid arthritis (33.6%). After the 1st dose, 1.45% of patients had COVID-19, 50% sought health services (emergency care), without the need for hospitalization and after the 2nd dose, 1.5% had the disease, of which none sought health services, required hospitalization or had a negative outcome. After the 3rd dose,: 2.9%were infected with SARS-CoV-2 one month later, 15.6% two to three months later and 5.5% four to six months later, all with laboratory confirmation;only 4% presenting any serious complication;there were no deaths. After the 4th dose, 9.1%of patients had COVID-19, of which 40%were hospitalized, without the need for assisted ventilation;half of these patients had a serious complication, but there no deaths. Conclusion(s): In this study, we observed the effectiveness of the vaccine in preventing severe cases of COVID-19 and complications of SARS-CoV-2 infection.
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Objectives: Chronic Inflammatory Immune-mediated Diseases (CIMD) can cause pain and severe discomfort to the patient, leading to significant reductions in his/her quality of life. Vaccination against COVID-19 has proven to be an efficient method in preventing cases and serious repercussions. However, there is insufficient evidence on the safety of these vaccines in the CIMD population. Objective(s): To assess disease activity in adolescent patients with CIMD after vaccination against SARS-CoV-2. Method(s): Observational, longitudinal, ambidirectional study with follow-up of groups of adolescent patients with CIMDwho received the vaccine provided by the National Immunization Program -Pfizer/BioNTech. Sociodemographic and clinical disease activity data were collected before and after each vaccine dose. Data were stored through an online platform (REDCap). This study is associated to the SAFER Project from the Brazilian Society of Rheumatology and was approved by the local Research Ethics Committee. Result(s): Nineteen adolescents aged between 12 and 17 years were included, all of whom met the inclusion/exclusion criteria. Of the total, 31.6% have Juvenile Idiopathic Arthritis (JIA)-14.33 +/- 2.25 years of age, whose subtypes included persistent oligoarticular JIA (16.7%), Polyarticular Rheumatoid Factor (RF) negative (33.3%), Polyarticular RF positive (16.7%) and Systemic (33.3%);68.4% have Systemic Lupus Erythematosus (SLE) -14.77 +/- 1.96 years of age. Regarding JIA patients, at inclusion, the mean disease activity assessed by the physician was 3 +/- 3.83 and 3.25 +/- 3.77 as assessed by the patient. After the 1st dose, the mean activity assessed by the physician was 2.8 +/- 3.9 and after the 2nd dose it was 3 +/- 4.24. Themean activity after the first dose as assessed by the patient was 3.2 +/- 3.96, and after the 2nd dose it was 2.8 +/- 3.11. In the SLE patients, at inclusion, the mean degree of disease activity was 1.92 +/- 1.83 and of the SLEDAI-2 K was 4.67 +/- 5.14. After the 1st dose, the mean disease activity was 1.11 +/- 1.96, and after the 2nd dose, it was 2.25 +/- 2.76. After the 1st dose, the SLEDAI-2 K was 1.11 +/- 1.76, and after the 2nd dose it was 4.25 +/- 5.28. No reports of worsening of disease activity after the vaccine were found. Conclusion(s): The vaccination proved not to contribute to worsening of clinical activity of rheumatic diseases in adolescents, without significant changes in SLE assessment indices and in the personal and medical assessment of JIA patients.
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Objectives: In the Chronic Inflammatory Immune-mediated Diseases (CIMD), infections mainly occur in the respiratory tract and their occurrence is related to drug-induced immunosuppression, underlying diseases and comorbidities. To reduce this morbidity and mortality, vaccination is an effective means of prevention. However, the available studies on SARS-CoV-2 vaccines have not addressed this group of patients with CIMD, and there are still many doubts regarding the indications, adverse effects, safety and efficacy of these vaccines. Objective(s): to evaluate the adverse effects of vaccines against SARS-CoV-2 in adolescent patients with CIMD. Method(s): Research associated to the SAFER Project from Brazilian Society of Rheumatology. It is an observational, longitudinal, ambidirectional study, with follow-up of groups of vaccinated adolescent patients with CIMD, vaccine by Pfizer/BioNTech. Sociodemographic data were collected, stored on an online platform, and adverse events were presented by filling in diaries issued for each patient. This study was approved by the local Research Ethics Committee. Result(s): We included 19 adolescents, aged between 12 to 17 years, who met the inclusion and exclusion criteria. The mean age was 14.63 +/- 2.01 years. Of these, 68.4% were female. In relation to CIMD, 31.6% have Juvenile Idiopathic Arthritis and 68.4% have Systemic Lupus Erythematosus. All were vaccinated with the Pfizer vaccine. In the 1st dose, the main adverse effects presented were Pain at the injection site (85.7%), Headache (42.9%), Tiredness (33.3%) and Edema and skin induration at the injection site (26, 7%). After the 2nd dose, the only adverse effect reported was Pain at the injection site (57.1%), with no other complaints. Conclusion(s): The adverse effects reported are of mild tomoderate reactogenicity;no serious adverse events were reported.
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Vaccines are an essential public health resource for disease containment and reduction of associated mortality rates. With the emergence of COVID-19, public debates on the themes of vaccines and vaccination processes became important topics on diverse media and social networking platforms. In this article, our objective was to identify and reflect on the emotions evoked in the Brazilian public with respect to the COVID-19 vaccine during 2020 and 2021 on Facebook. To achieve this, we used the Crowdtangle graphical interface to extract complete copies of posts made by public Facebook profiles during this timeframe, from which a random sample of 1,067 posts was selected for analysis. Identification of emotions was performed using the Human-Machine Interaction Network on Emotion (HUMAINE) descriptors as a baseline reference. Emotions were then grouped into categories following Core Affect Model guidelines. Data analysis and interpretation indicated a prevalence of positive emotions such as trust, interest, and hope directed toward vaccines in the Brazilian domestic scenario. Negative emotions such as worry and disapproval were also expressed, albeit in reference to contextual issues (for example, the spread of COVID-19, delays in vaccine access, and the emergence of new variants) and public figures, such as the President of Brazil. © COMUNICAR, 76 (2023-3)
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To analyze the design of educational governance for Basic Education that materialized in the first year of the Covid-19 pandemic in Amazonas, the article resumes and analyzes the decision-making of the public power on the municipal and state education systems of the capital and state between March 2020 and February 2021. Based on the Sociology of Public Action and a qualitative approach, the study that serves as the basis for this article – developed by researchers in the field of Education at the Federal University of Amazonas, based on an integrative review of the specialized literature, mapping and analysis of the actions of the education departments of Manaus and Amazonas – reconstructed the consolidated paths in the educational field in one of the epicenters of the pandemic in the country. The data reveal the complex network of public and private agents that engender the governance investigated here, the tensions between the comings and goings around the resumption of face-to-face classes, as well as alternative teaching models for the pandemic scenario and the deepening of public-private partnerships. © 2023, Ensaio. All Rights Reserved.
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Among the problems caused by the pandemic of the new coronavirus (SARS-COV-2), besides the irreparable loss of loved ones and the damage to global health caused by the disease, the restrictions imposed and the economic losses incurred by them stood out. Given the sudden changes imposed on the routine of society and companies, many businesses went bankrupt, while the other survivors needed to adapt quickly, resulting in a routine based on home office, ecommerce and distance learning. The educational sector was strongly affected by these restrictions, as well as the assets linked to it, as highlighted by the cumulative annual drop of 22% of the IFIX (index of Real Estate Investment Funds), witnessed by investors during the arrival and spread of the pandemic in Brazilian territory. Thus, the work was based on the prospective analysis of scenarios through the Momentum method, producing three possible future scenarios for the recovery of the educational REITs (Pessimistic, Optimistic, and Trend), with the help of three financial planning specialists. At the end of this study, it was possible to configure the scenarios: "The recovery of education REITs" as optimistic scenario, "Challenges of education REITs" as trend scenario, and "The crisis of education REITs" as Pessimistic scenario.
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The pandemic scenario is analyzed in this article focusing on the educational field and on the transformations and challenges faced by Basic Education schools. With the objective of analyzing the pendular tensions between suspension and return of face-to-face classes in the state of Amazonas in the first months of the Covid-19 pandemic, the article retraces educational governance in the first half of 2020. From the Sociology of Public Action, we demonstrate: the main consequences of the pandemic on education;the complex web of educational governance in times of a pandemic;and the struggles for hegemony from the movements between suspension and return of classes in schools in Amazonas.
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The period of the pandemic resulted in high levels of physical and emotional exhaustion in health professionals, pointing out issues related to health and prevention of worker illness. this study aimed to verify how the mental health of health professionals was impact because of their work in a Covid ICU. this is a systematic review on the impact of the Covid ICU work environment on the mental health of the health professional. The literature search included articles indexed in PubMed, Web of Science, Scielo and Periodical CAPES and SCOPUS during the month of June 2021. The search strategy used the following descriptors: "COVID-19" AND "ICU" AND "Mental Health" AND "Healthcare Workers". the present study identified 37 articles after searches in the databases, among these, 06 articles were select. Worsening of mental health variables were identified in all studies, evidencing the psychological impact of ICU professionals in the face of the COVID-19 pandemic. the need was identified for actions aimed at professionals working in an intensive care unit in order to implement regular mental health care.
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This study analyses the impact of the Covid-19 pandemic on the division of domestic work as regards women in opposite-gender relationships, telecommuting and living as a couple, during the first lockdown in Portugal. Quantitative and qualitative data was collected (N = 171) to understand women's perceptions of time spent on unpaid work, satisfaction, and main difficulties in this period. Results revealed women's dissatisfaction, especially mothers of underage children, who perceived an increase in caregiving tasks. Women's satisfaction also impacted their perception of the causes for these gender asymmetries. The less satisfied women ascribe gender inequalities mainly to socio-normative factors and gender stereotypes, while the more satisfied women ascribe them to aspects of socialisation and upbringing, as well as innate dispositions that differ between men and women. The trend towards more equality found prior to Covid-19 was not found. © 2022 Associacao Portuguesa de Estudos sobre as Mulheres. All rights reserved.
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As the COVID-19 pandemic ravaged the planet at a standstill, remote employment seemed inescapable. Still, for some businesses that rely on the on-site presence of employees, this was a lethal blow. As time passed, restrictions got looser and allowed people to strike a balance between on-site and remote work. Thus, tracking people's indoor movements for purposes involving activity inference, security, and contact tracing is more crucial than ever before. This research explores the applicability of (Radio Frequency Identification) RFID contactless smart cards in tracking people's movement within an enclosed establishment by building a proof-of-concept prototype that allows the mentioned purposes. Furthermore, the system underwent multiple test phases to verify that the system meets the functional and non-functional requirements listed to ensure the system's operational success. Consequently, the test results prove that: 1) the system is behaving as intended;2) the system is secure from known high-risk vulnerabilities;and 3) the system satisfies user requirements and standards, thus fulfilling the functional and non-functional requirements for a human-tracking movement system. © 2023 by the authors.
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The first reports of SARS-CoV-2 virus infection occurred in late 2019. Infection and the development of COVID-19 disease are directly related to the particular characteristics of the individual, such as gender, age, and comorbidities. Moreover, indi-vidualswho had some type of chronic disease expressed a higher rate of complications arising from the infection. This study aimed to verify the prevalence of comorbidities in individuals infected by COVID-19 in the city of Jaragua do Sul/SC from March 2020 to December 2021. The research presented a cross-sectional, descriptive, analytical design with a quantitative approach, carried out through secondary data using the Olostech in-formation system of the Health Department of the municipality. The results showed that 40,010 subjects were infected during the study period, of which 39,574 (98.9%) were recovered and 436 died (1.1%). It was observed a predominance of females in the recov-ered group (52.3%) and males in the deceased group (59.2%). The predominant age group in the group of recovered patients was 20-59 years (n=31,636;79.9%) and in the group of deaths it was 60 years or older (n=269;61.7%). In the year 2021 there were more cases of recovered (n=26,040;65.1%) and deaths (n=342;78.4%) when compared to the year 2020. The mean age in the recovered group was 37.5 +or- 15.8 years and in the death group was 63.2 +or- 15.7 years. The data showed the profile of infected individuals and the prev-alence of the main chronic diseases: hypertension, diabetes and obesity. We suggest ac-tions and strategies aimed at minimizing these comorbidities, aiming at a better quality of life for individuals in this city.
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Introduction: higher value of urea/albumin (U/A) ratio is associated with higher risk of death in patients with pneumonia. It is known that infections by COVID-19 can lead to ICU admission and death, and, in this scenario, the evaluation of this marker can be useful to improve the management of these patients. Objective(s): to evaluate the U/A ratio as a predictor of mortality in patients hospitalized for COVID-19. Method(s): 252 unvacinated patients with COVID-19 hospitalized between April 2020 and February 2021 were included in this cohort and were assessed by complete blood count and laboratory analysis on the first and third day of hospitalization. Result(s): Of the total number of patients, 153 were hospitalized in a ward and, of these, 28 died. Of those who required intensive care (n=99) 72 died. The comparison of the U/A ratio was lower in survivors when compared to the dyed group on the first day of hospitalization (14.0+/-10.3 vs 22.1+/-18.8;p<0.001) and on the third day (19.1+/-16.1 vs 28.3+/-16.8;p=0.005). The absolute variation in urea on the third day from baseline was also lower in the group of survivors (1.59+/-13.8 vs 30.9+/-37.9;p<0.001). The multiple logistic regression model adjusted for age, sex, place of hospitalization and C-reactive protein showed that the U/A ratio on the first day was associated with a higher risk of mortality [OR: 1.04;95%CI: 1.02-1.07;p=0.002]. The U/A ratio on the third day was not associated with risk of death whereas the absolute variation in urea showed an association with mortality [OR: 1.03;(95%CI: 1.01-1.05);p<0.001]. Conclusion(s): the use of the U/A ratio and the urea variation can predict mortality in patients hospitalized for COVID19.
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Post COVID-19 patients have been suffering from persistent symptoms even after long periods. The physiopathology of these clinical manifestations still has a lack of knowledge. The objective was to evaluate the total expression of metabolites and spittle biological pathways in patients with 60 days post COVID-19. We included 30 post-hospital discharge patients and we compared seven non COVID-19 patients control. All COVID-19 patients were assessed by demographic characteristics, pulmonary function, exercise capacity, quality of life and body composition. The metabolomic analysis was performed in the patient's splits. From the total of post COVID-19 patients, 66% were male, 60+/-14 years. The lean body mass was 30+/-7kg and fat mass 34+/-13kg. Spirometry mean severity showed FVC of 4+/-1L, FEV1 3+/-1L. Pimax and Pemax values were 90+/-31(cmH2O) and 97+/-31(cmH2O), respectively. The quality of life evaluated by the SGRQ questionnaire showed a mean percentage of magnitude of symptoms 32+/-15, activities 41+/-25, impact 13+/-11 and total of 24+/-15. Physical capacity was measured by the distance in the 6MWT, and presented an average of 413+/-131. The metabolomic analysis showed 19 metabolites statistically significant difference between groups. We observed 3 metabolites overexpressed and 16 with lower expression in post COVID19 patients. From those metabolites, we can have attention to Sphinganine(p=0.03), Piperenol A triacetate(p=0.02) and 1-Monopalmitin(p=0.03) were lower expressed in control group. The creatin was one of the non-expressed metabolites in post hospital discharge COVID-19 patients compared to the control group. Thus, metabolomic analysis can demonstrate different metabolites in post COVID-19 patients to answer persistent symptoms.
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The COVID-19 brought several new challenges for the students and lecturers, particularly in higher education. The conventional physical classroom was almost instantly pushed into a new environment: a remote session class. And this lecturing paradigm shift occurred, necessarily, in a short period of time. The lecturing players suffered the pressure of using different learning tools and methodologies while exposing themselves to, in most part of cases, unexpected cybersecurity threats. The purpose of this article is to clarify all the new menaces that arose during this period. Also, to understand the level of exposure and impacts on the lecturer and student to this quick but necessary paradigm shift. Methodologically: two focus groups were undertook to capture representations of students about uses of computer technology;differences in exposure to threats before and during the pandemic and impacts on society;student's needs regarding the topic and suggestions about strategies for increasing overall knowledge about it. Answers were treated recurring to software webQDA®—Qualitative Data Analysis Software for analysis of qualitative data. Results depict the exposure to cybersecurity issues and some level of knowledge about them, inducing preventive practices when using informatics technology. Sense of increasing insecurity in society is associated with the statement of increasing activity regarding cybercrime, giving way to the assumption of the need of awareness and knowledge of general public regarding this issues, and rise suggestions on teaching approaches directed to the subject. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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Background and Objective. Convalescent plasma therapy (CPT) may reduce the risk of disease progression among patients with COVID-19. This study was undertaken to evaluate the efficacy and safety of CPT in preventing ICU admission among hospitalized COVID-19 patients. Methods. In this open-label randomized controlled trial, we randomly assigned hospitalized adult patients with COVID-19 in a 1:1 ratio to receive convalescent plasma as an adjunct to standard of care or standard of care alone. The primary endpoint was ICU admission within first 28 days of enrolment. Primary safety endpoints include rapid deterioration of respiratory or clinical status within four hours of convalescent plasma transfusion and cumulative incidence of serious adverse events during the study period including transfusion-related acute lung injury (TRALI), transfusion-associated circulatory overload (TACO), severe allergic reactions, and transfusion-related infections. Results. A total of 22 patients were assigned to receive convalescent plasma as an adjunct to standard of care and 22 to receive standard of care alone. The median time from onset of COVID-19 symptoms to study enrolment was eight days (IQR, 4 to 10). Two patients (9.1%) in the CPT group and one patient (4.5%) in the control group were admitted to the ICU. The primary outcome measure, ICU admission, was not different between the two groups (q-value >0.9). No patient who received convalescent plasma had rapid deterioration of respiratory/clinical status within four hours of transfusion and none developed TRALI, TACO, anaphylaxis, severe allergic reactions, or transfusion-related infections. There was also no significant difference in the secondary outcomes of 28-day mortality (two patients in the CPT group and none in the control group, q-value >0.90), dialysis-free days, vasopressor-free days, and ICU-free days. Conclusions. Among hospitalized COVID-19 patients, no significant differences were observed in the need for ICU admission between patients given CPT as adjunct to standard of care and those who received standard of care alone. Interpretation is limited by early termination of the trial which may have been underpowered to detect a clinically important difference. © 2023 University of the Philippines Manila. All rights reserved.